HOTAIRM1 and leukemia: Among these lncRNAs, HOXB-AS3 is particularly interesting, because of the crucial roles of HOX genes in cell proliferation, hematopoiesis and leukemogenesis [36, 38, 39] and the clinical significance of an anti-sense lncRNA in the HOX clusters, i.e., HOTAIRM1, in leukemia [40].