ACHE and Alzheimer disease: People with dementia caused by neurodegenerative diseases such as Alzheimer’s disease (AD) or Lewy body dementia (LBD) and a specific range of cognitive decline may benefit from treatment with acetylcholine esterase inhibitors [3] and memantine [4] if tolerated [5], while the latter has no effect and may even worsen behavioural and cognitive symptoms in frontotemporal dementia (FTD) [6].