ACE and Stroke: Thus, for ACE inhibitors, MR estimates are given per 21.14 mm Hg decrease, for BBs per 9.51 mm Hg decrease, and for CCBs per 8.90 mm Hg decrease.3 MR analysis using the single genetic variant identified for ACE inhibitors showed a protective effect on stroke (relative risk [RR], 0.21; 95% CI, 0.06–0.72; P=0.01) but not CHD risk (RR, 0.67; 95% CI, 0.16–2.56; P=0.58).