Further in vivo investigation in a model of colitis in mice administered with persimmon phenolic extract, showed decreased levels of expression of COX-2 and inducible nitric oxide synthase (iNOS) in the colonic tissue, these being two important mediators of intestinal inflammation, but there was no inhibition of gelatinase MMP-9 and MMP-2 activities. This evidence concerns the gene NOS2 and colitis.