ITGB4 and familial pancreatic carcinoma: To evaluate the role of pancreatic cancer-derived EVs in the pre-metastatic niche, GO analysis revealed that abundant cellular adhesion proteins exist in pancreatic cancer-derived EVs, particularly integrins, such as ITGA1, ITGA2, ITGA3, ITGA6, ITGAV, ITGB1, ITGB4, ITGB5, ITGB6, and ITGB8 (Figure 3a,b).