We found that NL4-3, but not 81A, up-regulated many genes in human MDM, including TNF2, Fas (TNFRSF6)-associated via death domain [63], caspase-7, Cytocrome C, KGF [64] and GSPT1/eRF3 [65] but down-regulates survival and cancer genes. The gene discussed is FAS; the disease is cancer.