MAT1A and hepatocellular carcinoma: Indeed, the induction of MAT1A expression in liver tumor Hep3B and HepG2 cell lines by the individual knockdown of miR-664, miR-485-3p, or miR-49, which are upregulated in HCC cells, inhibits the proliferation and induces apoptosis, while the combined knockdown exerts additional effects on the same parameters [68].