Furthermore, AMPK upregulation in cancer cells activates phosphofructokinase 2 (PFK-2), a key enzyme of glycolysis [141], and CHIP (carboxyl terminus of Hsc70-interacting protein), a U-box E3 ligase, inhibits the aerobic glycolysis and the progression of ovarian cancer by inhibiting PFK-2 [142]. Here, PFKFB3 is linked to cancer.