Factor-specific treatments cover mainly hemophilia A and B, but also other disorders such as fibrinogen deficiency (plasma-derived [pd]fibrinogen), FVII deficiency (pdFVII concentrate), FX deficiency (combined FIX/FX concentrate or a recent high-purity pdFX [17]), and FXI deficiency (pdFXI product) have disease-specific treatments. Here, F11 is linked to hyperinsulinemic hypoglycemia, familial, 4.