Coagulation deficiencies, characterized by a different degree of severity depending on the affected protein and the corresponding residual levels, show either X-linked (FIX/FVIII deficiency) or autosomal (fibrinogen, prothrombin, FV, FVII, FX, FXI, FXIII deficiency) inheritance patterns. The gene discussed is F2; the disease is hyperinsulinemic hypoglycemia, familial, 4.