AKR1A1 and metabolic dysfunction-associated steatotic liver disease: Nonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease; alcohol dehydrogenase and aldehyde dehydrogenase collectively showed altered expression and function in the progression of nonalcoholic steatohepatitis (NASH) patients, which may also lead to significant alterations in the pharmacokinetics of substrate drugs.