FOXC1 and acute promyelocytic leukemia: In addition, we showed that in diagnostic APL samples and in NB4 cells, reduced FOXC1 expression was associated to DNA hypermethylation of the +354 to +568 FOXC1 region and that hypomethylating treatment with decitabine of NB4 upregulated FOXC1 expression [42] (Table 1).