Although, FOXO genes (FOXO1, FOXO3, FOXO4 and FOXO6) are frequently reported as tumour suppressors in several cancers [27,28,29,30,31,32,33,34,35], Lin et al. recently highlighted a new role of FOXO1 as an oncogene, clearly showing that the role of Forkhead box proteins depends on cellular context [19]. This evidence concerns the gene FOXO1 and neoplasm.