As a matter of fact, FOXM1 is overexpressed in multiple types of cancer, similarly to NPM1, being upregulated in highly dividing cancer cells and associated with genomic instability and aneuploidy signatures, although the latter is not the case of NPM1 mutated AML whose one of the main feature is harboring a normal karyotype [64,65]. This evidence concerns the gene FOXM1 and acute myeloid leukemia.