Discovered approximately 10 years ago by Marcucci et al. [90], hot spot mutations in IDH1 (R132) and IDH2 (R140 and R172) occur in approximately 20–30% of patients with cytogenetically normal AML, 7–14% for IDH1 and 8–19% for IDH2 clustering in the region of isocitrate binding and with an uncertain impact on survival outcomes [90,91,92]. This evidence concerns the gene IDH2 and acute myeloid leukemia.