EGFR and nervous system disorder: Estrogenic activity is mediated by many molecular mechanisms and cell signaling pathways, such as angiogenesis, ErbB/HER, mitogen-activated protein kinase (MAPK), nuclear receptor, and ubiquitin/proteasome signaling pathways, and resulting in cell functions, such as apoptosis, autophagy, cell cycle/DNA damage/cytoskeletal formation, cellular metabolism, chromatin/epigenesis, development/differentiation, immunology/inflammation response, neurological diseases, and translational control [35].