EGFR and nervous system disorder: Estrogenic signaling pathways include angiogenesis, ErbB/HER, MAPK, nuclear receptor and ubiquitin/proteasome signaling pathways, and the pathways related to apoptosis, including autophagy, cell cycle/DNA damage/cytoskeletal formation, cellular metabolism, chromatin/epigenesis, development/differentiation, immunology/inflammation response, neurological diseases, and translational control [98].