AKT1 and neuropathic pain: Central sensitization is mainly produced by activated microglia and the release of bioactive mediators, including phosphoinositide 3-kinase (PI3K)/ protein kinase B (Akt), nuclear factor-κB (NF-κB), and mitogen-activated protein kinases (MAPK), which facilitate pain signaling in the peripheral and central nervous system, thus contributing to neuropathic pain [3,4,5,6].