According to the Hill and Hosking classification, CMA may manifest in three different ways: (1) The IgE-sensitized group showing immediate cutaneous reactions and anaphylaxis; (2) the non-IgE-sensitized group with gastrointestinal (GI) symptoms, developing within hours after ingesting moderate amounts of CM; and (3) the group with GI disturbances with or without respiratory symptoms and/or eczema/urticaria, occurring after several hours or days [10]. The gene discussed is IGHE; the disease is anaphylaxis.