Prognostic factors for poorer OS were also identified including ECOG Performance Status 1 or 2 (vs. 0), Barcelona Clinic Liver Cancer Stage C (vs. B), presence of microvascular invasion, high tumor burden, maximum baseline target lesion size >6 cm, AFP >200 ng/mL, high bilirubin, low albumin, albumin-bilirubin grade 2 (vs. 1), high neutrophil-lymphocyte ratio, and low ALP. This evidence concerns the gene AFP and liver cancer.