Because phosphorylation at Ser577, which occurred either by the action of PKA or by autophosphorylation, cause the cytoplasmic localization of SIK1 and thus results in a reduction of the transcriptional modulating activity of SIK1 [6], we speculated that hyperglycemia might enhance PKA-mediated phosphorylation at Ser577 or autophosphorylation at Ser577 under diabetic conditions, thus leading to a significant increase in the level of SIK1 phosphorylation at Ser577, but further elucidation of phosphorylation of SIK1 at Ser577 will be needed in the condition of diabetes. Here, SIK1 is linked to Hyperglycemia.