Seung-Hoi Koo et al. [9] reported that knockdown of SIK1 in mice promoted both fasting hyperglycaemia and gluconeogenic gene expression, whereas mice treated with adenovirus-expressed SIK1 (Ad-SIK1) exhibited fasting hypoglycaemia and reduced gluconeogenic gene expression, and Ad-SIK1 was also effective in reducing blood glucose levels in fasted db/db diabetic mice. Here, SIK1 is linked to Hyperglycemia.