TP53 and ependymoma: Previous studies stated that predictors of poor clinical behavior in intramedullary ependymoma patients included age less than 3 years, p53 immunopositivity, a high proliferation index, and incomplete resection.[29–31] It has been reported that younger age was associated with improved long-term survival.[32] Alshaya et al[33] stated that younger age was the only risk factor for patients with TR of the lesion.