GPX4 and cancer: Studies showed that cancer cells with mesenchymal state harboured a higher activity of enzymes that promote the synthesis, storage and use of long‐chain PUFAs, which are the sources of reactive lipid peroxides, making these cancer cells highly dependent on GPX4 for survival (Figure 3).80 This vulnerability makes it possible to induce ferroptosis in these cancer cells through inhibition of GPX4.