Mutations in the GJB1 gene, that encodes Cx32, cause X-linked Charcot–Marie–Tooth disease (CMT1X), the second most common type of inherited demyelinating neuropathy, which is often associated with subclinical and sometimes clinical manifestations of CNS involvement as well [18]. This evidence concerns the gene GJB1 and X-linked Charcot-Marie-Tooth disease type 1.