RECQL and Down syndrome: RecQ family of DNA helicases includes RECQL1, Bloom syndrome gene (BLM), Werner syndrome gene (WRN), RECQL4, and RECQL5. They play overlapping as well as unique functions in DNA replication and damage (especially double‐strand breaks) repair.10 Bloom and Werner syndromes are characterized with premature aging and predisposition to cancer.11 Mutations in RECQL4 are associated with Rothmund‐Thomson syndrome (RTS), another premature aging and cancer predisposition disease.11 More recently, mutations in RECQL1 were found in familial breast cancer patients.12, 13