KYAT1 and cancer: The glutaminase II pathway has been studied in many hyperammonemic diseases of the liver and urea cycle.18, 30, 31, 32, 33 However, the role of the glutaminase II pathway in cancer has been largely overlooked thus far.13, 34 In the present study, we found GTK, an intermediary enzyme of the glutaminase II pathway, to play a vital role in pancreatic tumorigenesis.