Cyst(e)inase treatment did not lead to induction of GCL-C or thioredoxin 1 although the differences in thioredoxin 1 protein levels were maintained in all three cell lines during cyst(e)inase treatment (BxPC3 > MIA-PaCa2 > Panc1) (Fig. 4c). Here, GCLC is linked to cyst.