Mutations in the ATM gene are associated with the human syndrome Ataxia Telangiectasia (AT), whose clinical phenotypes are similar to those of ATLD and include neurodegeneration, sensitivity to IR, immunodeficiency, premature aging, radiosensitivity and predisposition to cancer (Shiloh and Ziv, 2013; Rothblum-Oviatt et al., 2016). This evidence concerns the gene ATM and ataxia telangiectasia.