HLA-DRB1 and juvenile idiopathic arthritis: This has been of great use in JIA, whereby two studies identified novel susceptibility loci for different subtypes of the disease: HLA-DRB1*11 was uncovered as a strong systemic JIA (sJIA) risk factor following a meta-analysis of 9 independent case-control populations consisting 982 patients and 431 healthy children (11), while 9 new oligoarticular and rheumatoid factor (RF)-negative polyarticular JIA loci including PRR9_LOR and ILDR1_CD86 were identified from three cohorts comprising of 2,751 patients and 15,886 controls (13).