The presence of amino acid serine at position 11 in HLA-DRB1 was shown to confer an increased risk of uveitis (OR 2.60) in female JIA patients (31) and 17 non-HLA variants were found to be statistically significant for a diverse range of clinical outcomes, such as actively inflamed joints and joints with limited range of motion, in a Nordic cohort of 193 patients of all subtypes excluding sJIA (15). This evidence concerns the gene HLA-DRB1 and juvenile idiopathic arthritis.