HLA-DRB1 and juvenile idiopathic arthritis: This is in line with the discovery of HLA-DRB1*11 as a strong sJIA risk factor with an overall Odds Ratio (OR) of 2.3, and HLA-DRB1*04 with a pooled OR of 1.9 from a meta-analysis of prior candidate gene studies of MHC II in JIA (11, 12).