The results provided in this study are applicable to studies of TET2 in human cancers and may explain some of the previous SNP associations, such as rs7679673 of TET2 correlating with a family history of prostate cancer (Eeles et al., 2009; Haiman et al., 2011; Nickerson et al., 2013; Al Olama et al., 2014). This evidence concerns the gene TET2 and cancer.