TET2 and cancer: The TET2 protein plays an important role in the epigenetic regulation of gene expression during embryogenesis (Dawlaty et al., 2013), differentiation of hematopoietic cells (Ko et al., 2011), cancer development (Ito et al., 2010; Ko et al., 2010; Zhang et al., 2010; Meisel et al., 2018), and it is involved in somatic cell reprogramming (Doege et al., 2012; Costa et al., 2013).