YAP1 and cancer: Over the last 15 years the oncogenic cooperation models (RasV 12 scrib-) have resulted in an improved understanding of the addiction to Yki activation in cancer cells (Ma et al., 2018), the interaction of Yki with other signaling pathways (Zecca and Struhl, 2010; Sun and Irvine, 2013; Enomoto et al., 2015a; Piersma et al., 2015), and ectopic activation of network of transcription factors (Kulshammer et al., 2015; Atkins et al., 2016).