In the oncogenic cooperation model of epithelial RasV 12 scrib- tumors, the interactions between JNK and JAK-STAT pathways was detected as activation of JNK caused induction of Unpaired 3 (Upd3, Drosophila IL-6 like cytokine) resulting in systemic induction of JAK-STAT signaling that promotes tumor growth (Brumby and Richardson, 2003; Igaki et al., 2006; Pastor-Pareja et al., 2008; Wu et al., 2010). The gene discussed is MAPK8; the disease is neoplasm.