The epithelial tumor models of oncogenic cooperation which involved activation of oncogenes in polarity deficient cells (e.g., RasV 12 scrib-) result in increased Yki activity which is required for aggressive tumor growth (Brumby and Richardson, 2003; Uhlirova et al., 2005; Suijkerbuijk et al., 2016). This evidence concerns the gene YAP1 and neoplasm.