CASP3 and bronchopulmonary dysplasia: Consistent with this, our results revealed that compared with the air control group, the expression of AQP-1 in hyperoxia group was significantly decreased, and the expression level of caspase 3 was increased in this group, meanwhile, compared with hyperoxia group, the expression of AQP-1 in celecoxib treatment group was significantly increased, while the activated caspase 3 in this group was decreased, which suggests that AQP1 may have preventative effect on apoptosis and degree of pulmonary injury during BPD development.