The accumulation of secondary bile acids in the livers of HFD mice suppresses anti-tumor immunity through a PTGER4 receptor on CD8 cells, which is mediated by the Toll-like receptor 2 (TLR2) signaling pathway, thereby contributing to liver cancer progression (Yoshimoto et al., 2013; Loo et al., 2017). The gene discussed is TLR2; the disease is neoplasm.