Endothelial cells of tumor neo-vessels, over-expressed a string of DEGs correlated with the signaling pathways that govern tumor angiogenesis, including the vascular endothelial growth factor receptor 3 (VEGFR3 or FLT4), HIF-1A, ANGPT2, Metalloproteinases (MMP11 and MMP15) and Integrins (ITGA2, ITGAE, and ITGB1BP1). This evidence concerns the gene MMP15 and neoplasm.