So, although protein levels of individual mitochondrial-dynamics related proteins (e.g., Drp1) have been related to increased levels of malignancy (25), the global changes in mitochondria-related gene expression that we studied (Figure 1), clustered breast cancer samples according to tumor subtypes and seem to be related to changes in mitochondrial function rather to a specific mitochondrial morphology. This evidence concerns the gene DNM1L and neoplasm.