In our previous report (18) MC3 showed strong anti-proliferative and pro-apoptotic effects in pancreatic cancer cells namely Bxpc3 (mutant p53; Y220C), Miapaca2 (R248W), the gemcitabine-resistant ASPC1 (R273H) as well as Panc1 (R273H). Here, TP53 is linked to familial pancreatic carcinoma.