2001). Oncogenic disruption of the cell cycle machinery (such as upregulation of CDK2 and cyclin A) is a universal phenomenon in liver cancer (Lu et al. 1997; Molenaar et al. 2009; Shapiro 2006). In addition, previous studies have shown that the lack of these two genes induces cell apoptosis (Kasten and Giordano 1998; Meikrantz et al. 1994; Rivera et al. 2006). The gene discussed is CCNA2; the disease is liver cancer.