We noted no obvious histological signs of neurodegeneration,16 as opposed to the homozygous Clcn7 knock-out21,27,49 and Clcn7G213R homozygous knock-in16 mice that recapitulate the clinical manifestations of autosomal recessive osteopetrosis, but we observed behavioral changes associated with anxiety and depression. Here, CLCN7 is linked to depressive symptom measurement.