TNFSF13B and autoimmune disease: When BAFF binds its receptors it induces B-cell maturation, survival and development, but also contributes the activation of T cells, a hallmark of autoimmune diseases.25,30,35 Thus, BAFF is an ideal target for autoimmune diseases associated with lymphocyte hyperactivity, and the neutralization or elimination of BAFF can significantly ameliorate disease severity or suppress the development of autoimmune disorders.36