Further, sera derived from pT181-Qβ, but not Qß-, vaccinated Non-Tg mice was able to detect classical somatodendritic pTau+ structures in the autopsy brains of human FTD (Fig. 2h), and intracellular pathological inclusions of tau in neurons as well as tau accumulations in dystrophic neurites in the peri-plaque regions in human AD tissue (Fig. 2k–l). This evidence concerns the gene MAPT and frontotemporal dementia.