MAPT and tauopathy: Recent work, investigating pathological tau (tau294–305) conjugated to a Hepatitis B-core VLP was shown to induce immunity against tau, reduce truncated tau and rescue behavior in a P301S mouse model of tauopathy.45 However, since many modifications in tau (including phosphorylation, truncation, oligomerization, etc.)have been demonstrated to contribute to disease pathogenesis, the most effective epitope of tau for immunological targeting is still debatable.