MAPT and Brain atrophy: Immunization with pT181-Qß reduces tau pathology, prevents neuronal cell death, rescues brain atrophy, and preserves delay-dependent and spatial memory in the rTg4510 mouse model of tauopathy (models the familial form of tauopathy called frontotemporal dementia and parkinsonism linked to chromosome-17—tau type or FTDP-17T, with a single P301L point mutation in the exon 10 of MAPT).