Galanin, a 29-amino acid peptide hormone, is widely distributed throughout the central and peripheral nervous systems as well as other tissues (21) to modulate depression (22-24), cognition, neuroendocrine, Alzheimer’s disease (25), neuronal differentiation (26), pain threshold (27), food intake and energy homeostasis (28). Here, GAL is linked to early-onset autosomal dominant Alzheimer disease.