NUMB and leukemia: In this regard, studies of Ito et al. and Kharas et al. in 2010 were the first studies that have shown the relationship between the Msi2 inducer of the Msi2-Numb pathway and hematopoietic malignancy, and their investigations indicated the Msi2 portion and its regulative interactions with leukemia in a stable and definitive manner (38, 70).