Another study by Kharas et al. also showed that Msi2 inhibition by shRNA reduces cell proliferation and significantly induces apoptosis of Nomo-1 and THP-1 (AML), the LAMA-84 and AR230 (CML) cell lines (70). This evidence concerns the gene MSI2 and chronic myelogenous leukemia, BCR-ABL1 positive.