CNOT3 and adenoma: To confirm our previously published observation that five of twenty-five (20%) FAP adenoma samples carry CNOT3 mutations [13], we further interrogated the mutational status of CNOT3 in colorectal premalignancy by performing deep sequencing in all the exons using Ion Torrent (IT) in a new cohort of 37 adenomas of 14 FAP patients with paired germline samples (Supplementary Tables 2 and 3).