Gene expression meta-analysis yielded 34 significant metabolic genes that are underreported with fewer than five PubMed abstracts as targets in breast cancer research, including NUDT12, FAR1, PDE7A, FAHD1, BLVRA, ITPK1, SORD, HACD3, B4GALT5, CDS2, PPIP5K2, PDSS1, UGP2, GAMT, PLCH1, MAN2B2, AHCYL1, SEPHS1, ATP5S, LCMT2, NT5DC2, AK4, CSAD, GLUD1, PDXK, ADCY6, COX6A1, NME5, PIGH, COX4I1, COX6C, LIPG, LPIN1 and ABAT (Table 2). This evidence concerns the gene AK4 and breast cancer.