In this patient, the high-grade dysplastic epithelial cells showed strong nuclear FLI1 expression (Figure 1N*, mean H-score = 151.5), but the deepest invasive tumor epithelial cells showed almost absent nuclear signal (Figure 1O*, mean H-score = 35), suggestive of a stepwise downregulation of FLI1. Gastric adenocarcinomas in the TMAs showed variable levels of nuclear FLI1 expression, but 96% of these tumors had an H-score less than the mean score for normal gastric glands. This evidence concerns the gene FLI1 and neoplasm.