SP1 and hydrops fetalis: A major finding of the present study is the identification of specific and novel miRNA that are targeting HF- regulating genes (Figure 1D), i.e., miR-125b (SP1), mi199a, miR-7e, miR-106a, and miR-106b (KLF3), miR-140 miR-146; miR-188, miR-143, miR-125a, miR-19b, and miR-105 (MYB), miR-23b and miR-29a (BCL11A and SP1).