Also, based on our finding of increased inflammatory phenotype of dendritic cells in Gal-3 deficient mice immunized with xenobiotic and adjuvant (9) and known role of Gal-3 in attenuation of TLR agonist induced inflammation (43, 44) it can be assumed that Gal-3 attenuates activation of dendritic cells with mixture of xenobiotic and adjuvant and thus contributes to attenuation of xenobiotic induced PBC. This evidence concerns the gene LGALS3 and primary biliary cholangitis.