IL1RL1 and Increased total eosinophil count: First discovered in humans in 2003 where it was found to be constitutively expressed in the nucleus of cells in barrier tissues throughout the body, IL-33 was further characterized by Schmitz et al. as a cytokine that induced TH2 cytokines and eosinophilia in vivo via binding to what was then the orphan cytokine receptor T1/ST2 (ST2) (121, 122).