Therefore, we explored whether mRNA electroporation of CXCR4, including the WHIM syndrome naturally occurring GOF mutated variant CXCR4R334X, could be utilized to alter the expression of CXCR4 on the surface of expanded NK cells and improve their migration toward its ligand SDF-1α and in vivo homing to BM compartments in mice. This evidence concerns the gene CXCR4 and WHIM syndrome.