Based on this data, we concluded that TLR7 rs3853839 G-risk allele is a strong factor in the TLR7 increase but, since not all of the SLE TLR7hi subjects had the TLR7 rs3853839 G-risk allele; other factors also are likely contributing to the increase of TLR7 expression. The gene discussed is TLR7; the disease is systemic lupus erythematosus.