TLR7 and systemic lupus erythematosus: The frequency of the TLR7 rs3853839 G-risk allele is considerably higher in Asians, relative to Caucasians or African-Americans [C: 22%, G: 78% vs. C: 83%, G:17% and C:81%, G: 19% respectively (data from 1000 Genomes)], suggesting that the G-risk-associated phenotype might be more prevalent in Asian SLE patients.