Reactivity against nineteen auto-Ags, including dsDNA, ssRNA, Nucleolin, ssDNA, Chromatin, Sm- and SmD-Ags, RPPs, U1-snRNP-C, Histone H2A, and gp210 were higher in the TLR7hi SLE group, as compared to the TLR7norm/lo group (Figure 4B and Table 2). The gene discussed is NUCLEOLIN; the disease is systemic lupus erythematosus.