Two recent studies show an association between TLR7 rs3853839 G risk allele and the development of lupus nephritis or other manifestations of SLE, including malar rash, photosensitivity, pericardial effusion, reduced complement, and anti-dsDNA and anti-Sm auto-Abs (23, 59). The gene discussed is TLR7; the disease is systemic lupus erythematosus.