To further understand how the increase in TLR7 expression might affect B cells and auto-Ab production in SLE patients, we tested IgM and IgG autoantibodies in serum samples from HCs (n = 4), SLE TLR7norm/lo (n = 8) and SLE TLR7hi (n = 8) patients using autoantigen array. Here, TLR7 is linked to systemic lupus erythematosus.