CD8A and neoplasm: Characterization of immune cells in the IL-33-expressing tumors revealed a local increase in CD8+ T cells and NK cells, with increased expression of type 1 effectors such as IFN-y, IL-12 and granzyme B. Moreover, IL-33 was shown to regulate local tumor-associated myeloid cells and enhance the expression of MHC II as a result of the type I immune response (108).