Recent studies have shown that incubation of NK cells with IL-18, IL-12, and IL-15 results in the generation of cytokine-induced memory-like (CIML) NK cells, which have enhanced cytokine (IFN-γ) production and exhibit potent anti-tumor effects against both hematological (76) and non-hematological malignancies (77). Here, IL18 is linked to neoplasm.