Given the critical importance of such pathways in tumor formation, links between the IL-33/ST2 signaling axis and tumorigenesis have recently been identified, with multiple research groups implicating IL-33 as a key player in the mediation of neoplastic transformation, tumor growth and metastasis in various cancers including breast, gastric, colorectal and lung (85). The gene discussed is IL1RL1; the disease is neoplasm.