In initial experiments antigen-activated OT-I CD8 T cells were transferred to cultured RFP+ B16.cOVA cells along with the caspase 3/7 detection reagent, and tumor cell death was monitored over time as RFP+Casp3/7+ in the presence or absence of 10 or 20 μM OTP. This evidence concerns the gene CASP3 and neoplasm.