Further evidence that LPA5 signaling is indeed responsible for impaired in vivo CD8 T cell cytotoxicity was observed after implanting the syngeneic EL4 lymphoma variant, EG7 (53), into either C57BL/6, Lpar5−/−, or Rag2−/− hosts and measuring lymphoma growth 12 days later. The gene discussed is CD8A; the disease is lymphoma.