In contrast to RB1, the exosome endoribonuclease DIS3 is mutated in ~10% of NDMM and ~75% of these mutations occur in del(13q) myeloma suggesting biallelic loss of DIS3 occurs in most DIS3 mutated myeloma (66, 89, 90). The gene discussed is RB1; the disease is plasma cell myeloma.