Organ specific control was described also in candidate gene based studies of parasite burden after infection with L. donovani, where genes Slc11a1, H2 (25) and Lyst (24) control parasite load in spleen, whereas Slc11a1 (26), H2 (27, 28) and Ir2 (28) determine parasite load in liver. This evidence concerns the gene LYST and infection.