Further, CpG-ODN (oligodeoxynucleotides (ODN) with cytocine-guanine-rich (CpG) motifs) vaccination caused up-regulation of ICAM-1 and VCAM-1 on tumor-associated blood vessel endothelia leading to strong tumor-infiltration of adoptively transferred tumor-specific T cells and tumor suppression in mouse model of pancreatic islet cell carcinoma (301). Here, VCAM1 is linked to neoplasm.