High expression of L-selectin has been shown to mark Tregs with more potent ability to inhibit graft-versus-host disease (GVHD) and bone marrow (BM) graft rejection in mice compared to L-selectinlo Tregs (172) and αE+ Tregs have been shown to be more effective in suppressing acute inflammatory reactions in the induced SCID colitis model and antigen-induced arthritis model compared to αE negative Tregs (173, 174). The gene discussed is SELL; the disease is graft versus host disease.