Interestingly, Anz et al. discovered that integrin αE (CD103) is expressed at significantly higher levels in tumor-infiltrating Tregs in several mouse cancer models compared to other peripheral Tregs (90% in CT26-infiltrating Tregs vs. 20% in splenic Tregs) due to increased levels of TGFβ in the tumor microenvironment (179). This evidence concerns the gene ITGAE and neoplasm.