In addition, mainly anti-ICAM-1 and anti-VAP-1 and to a lesser extent anti-VCAM-1 mAbs inhibited HCC-derived T cell binding to tumor vascular endothelium in vitro suggesting that LFA-1/ICAM-1 and VAP-1 receptor/VAP-1 are crucial pathways mediating T cell recruitment into the tumor site in HCC. Here, ITGB2 is linked to hepatocellular carcinoma.