Although the observations in mice suggested a stronger association with late- than early onset cataract, we included 308 patients with childhood (congenital) cataract and 360 patients diagnosed with age-related cataract (ARC) in the screen for sequence variants in the coding region and canonical splice sites of SLC7A8. We found one homozygous alteration: a deletion of one nucleotide leading to a Frameshift and a premature termination toward the carboxy terminus of the translated protein (c.1305del; p.Phe436Serfs∗22). This evidence concerns the gene SLC7A8 and Age-related cataract.